Sileo is a gel prescribed for dogs that suffer from noise aversion. This FDA-approved medication helps calm your dog when he is scared of loud noises. Some of the most common noises that scare your dog or makes him anxious are thunderstorms, fireworks, traffic, construction, loud music, vacuum cleaners, and smoke detectors. Sileo is a gel that is administered between your dog’s cheek and gum, using a syringe. Then the active ingredient (dexmedetomidine hydrochloride) in the gel is absorbed into the bloodstream, where he will block norepinephrine. Norepinephrine is a brain chemical, like adrenaline, that pumps up anxiety. Reduced levels of norepinephrine lead to reduce levels of anxiety and fear. Sileo will leave your dog relaxed and fully functional.